By Minoru Ueda (Ed.)

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208: 146,1985 (Kito K, Kagami H, Kobayashi C, Terasaki H, Ueda M) Chapter 3 Bone The use of dental implants in oral rehabilitation is becoming a standard method of care in dentistry. In the case of insufficient bone volume, a procedure for augmentation is needed. The ability to augment the alveolar ridge has gradually expanded the scope of implant dentistry. During the past 10 years, alveolar augmentation techniques have become established treatment modalities. Dahlin et al. reported an experimental study on rabbits involving the formation of new bone around titanium implants using the membrane technique [1].

93: 6476,1996 19. Kannan S, Tahara H, Yokozaki H. Telomerase activity in premalignant and malignant lesions of human oral mucosa. Cancer Epidemiol Biomarkers. 16: 413,1997 20. Kang MK, Guo W, Park NH. Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres. Cell Growth Differ. 9: 85,1998 21. Matsui M, Miyasaka J, Hamada K. Influence of aging and cell senescence on telomerase activity in keratinocytes. J Dermatol Sci.

25) and were similar to native bone. P P C T (a) (b) (c) Fig. 14. Schematic drawing of the surgical procedures used in this study (P, Periosteum; C, Cortical bone; T, Trabecular bone). (a) Dog mandibular defect model (4 × 4 × 3 mm). (b) Implant placement. (c) Transplantation PRP gel (left) and cultured periosteum membrane on PRP gel (right) (From Mizuno et al. 2008). The consensus tissue engineering paradigm includes cells, scaffolds, and bioactive molecules. For periodontal therapy, there are several reports based on this tissue engineering paradigm that incorporate various polymers such as collagen and gelatin as a scaffold material [29-31].

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