By Prof. Dr. H. Förstl (auth.), Prof. Dr. H.-J. Gertz, Prof. Dr. Th. Arendt (eds.)

As human toughness is still prolonged, so will the impression of age-associated dementia on person lives and society. Alzheimer’s sickness because the commonest explanation for dementia within the aged is still a sentinal challenge and its underlying pathology remains to be poorly understood. on hand healing innovations require massive refinement and the advance of recent healing thoughts want enter from simple learn. therefore persisted efforts are worthwhile either to appreciate simple mechanisms of the situation and to accomplish extra powerfull remedies. This quantity brings jointly the studies of simple scientists and medical investigators. The chapters supply a spectrum of knowledge precious for clinicians and scientists. This factor bridges the space among laboratory paintings in uncomplicated technology and the improvement of urgently wanted healing techniques. parts awarded are the molecular and mobile biology of the ailment, pathogenetic mechanisms and capability healing objectives, genetics, possibility components, suggestions of prevention and therapy in addition to useful elements of scientific and social deal with sufferers with Alzheimer’s disease.

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Arch Neurol 54: 641644 Almkvist 0, Jensen M, Basun H, Wahlund LO, Amberla K, Viitanen M, Lannfelt L (1997b) Elevated cerebrospinal fluid tau correlates with Alzheimer disease symptoms in apolipoprotein E E4( +) carriers. (submitted) Aronson MK, Ooi WL, Morgenstern H, Hafner A, Masur D, Crystal H, Frishman WH, Fisher D, Katzman R (1990) Women, myocardial infarction, and dementia in the very old. Neurology 40: 1102-1106 Mild cognitive impairment - an early stage of Alzheimer's disease? 27 Bondi MW, Monsch AU, Galasko D, Butters N, Salomon DP, Delis DC (1994) Preclinical markers of dementia of the Alzheimer type.

18 Cooper et al. (1996) minimal dementia and mild dementia n = 106 27 months 20 O'Connor et al. (1991) "minimal dementia" according to CAMDEX n = 29 1 year 2 years 21 50 Tierney et al. (1996a,c) memory-impaired, non-demented n = 123 2 years 24 Petersen et al. 5 years 24 44 55 Troster et al. (1996) non-demented cognitively normal subjects with memory complaint n = 35 4 to 6 years 13 Linn et al. (1995) free of dementia n = 1045 7 to 13 years Masur et al. , 1994). For all of these methods, some value could be demonstrated in the prediction of further decline to dementia in MCI patients.

Psychopharmacol Bull 24(4): 509-514 Dawe B, Procter A, Philpot M (1992) Concepts of mild memory impairment in the elderly and their relationship to dementia: a review. Int J Geriatr Psychiatry 443449 de Leon MJ, Golomb J, George AE, Convit A, Tarshish CY, McRae T, De Santi S, Smith G, Ferris SH, Noz M, et al (1993) The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. AJNR Am J NeuroradioI14(4): 897906 de Leon MJ, George AE, Golomb J, Tarshish C, Convit A, Kluger A, de Santi S, McRae T, Ferris SH, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller DC, The prognosis of mild cognitive impairment in the elderly 47 Wisniewski HM (1997) Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease.

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