By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)

The ailments that fall below the generalized crew of demyelinating ailments -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the focal point of globally crisis. This quantity comprises papers awarded through top scientists who attended the NATO complex study Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This publication is an replace of the former one released in 1987 of the examine mentioned at an analogous assembly held in 1986. It used to be determined to carry this 2d assembly due to the fact that there was nice development within the advances in realizing the myelinogenesis strategy within the final 5 years. The workshop collected jointly scientists from many fields akin to mobile and molecular biology, immunology, pathology, virology and naturally medical neurology. Stimulating rules have been exchanged within the desire that extra wisdom of demyelinating ailments may end up in new theraupetic methods. even though the workshop was once more often than not just like the former one, this time there has been extra emphasis on experimental types and medical elements. within the former using animal and mobile types as instruments for figuring out the pathological mechanisms associated with human disorder have been mentioned; within the latter the clinicians defined the filtering down of simple study to scientific therapy The booklet of this interdisciplinary trade is to make recognized the result of the newest examine one of the investigators from allover the area fascinated about those studies.

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Bosse, personal communication). An amplification product of the expected size of 524bp obtained by DNA-PCR is shown in Fig. 2A, lanes 2 and 3. No amplification product could be derived from the endogenous PMP22 gene (Fig. 2A, lane 1). This result proves the integration of the transduced PMP22 cDNA sequences into the host cell genome. To determine the orientation of the integrated PMP22 sequences we have applied a different strategy using one primer located within the vector sequence and another within the cDNA sequence.

This construction made it possible tQ determine by in situ hybridization whether the 5' end of the MBP message is invQlved in migration. [35S] labeled sense and antisense cRNAs were generated from a Hpal-Hpal fragment 'Of the lacZ sequence subcloned into the plasmid Bluescript. Hybridization of the antisense cRNAs with paraffin sections 'Of brains from 18 day-old line 4 transgenic mice shQwed that the transgene RNA was confined tQ the cell bodies. The intensity 'Of the hybridizatiQn signal 'Over cell processes and myelin sheaths was within the background range.

Recently, de Waegh et a1. 24, showed that close intercellular contacts between myelinating Schwann cells and axons modulate a kinasephosphatase system acting on neurofilaments. Our observation illustrates a reverse crosstalk between a myelinating cell and the axon. The mechanism by which axons activate the proximal portion of the MBP proximal promoter in the oligodendrocyte remains to be discovered. Acknowledgements We are greatly indebted to Drs. B. Rantsch, D. Colman, M. Dent, A. Frankfurter, B.

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